Sodium Hydroxide → HCID 10773402, compound

HRID 1623577Notes

Reaction equation

HRID 1623577 reaction equation
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH3:15])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH3:15])[CH:9]=[CH:8][N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 10750907HCID 10750907, compound

Product 1

HCID 10773402HCID 10773402, compoundYield 47.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

28.2 g of 2-acetoxymethyl-3-methyl-4-ethoxy-pyridine was added dropwise to a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. Subsequently, the reaction liquid was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 10.7 g of 2-hydroxymethyl-3-methyl-4-ethoxy-pyridine as an oily matter.

Workup

  1. customto react for one hour at room temperature
  2. customSubsequently, the reaction liquid
  3. washthe toluene phase was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-c00b027dd9ef463da7d483b811a2a7a6
Source dataset
uspto-grants-2014_07
Patent number
US08778975B2

Reaction notes

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