Sodium Hydroxide → HCID 68467548, compound

HRID 1623586Notes

Reaction equation

HRID 1623586 reaction equation
[CH2:1]([O:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][O:14]C(=O)C)[C:8]=1[CH3:18])[CH2:2][CH2:3][CH2:4][CH3:5].[OH-].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([O:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([CH2:13][OH:14])[C:8]=1[CH3:18])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68469332HCID 68469332, compound

Product 1

HCID 68467548HCID 68467548, compoundYield 60.8%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

22.0 g (0.088 mol, 1.0 eq.) of 4-pentyloxy-2-acetoxymethyl-3-methylpyridine was added dropwise to a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. Subsequently, the reaction liquid was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 11.2 g of 4-pentyloxy-2-hydroxymethyl-3-methylpyridine as an oily matter (yield 60.8%).

Workup

  1. customto react for one hour at room temperature
  2. customSubsequently, the reaction liquid
  3. washthe toluene phase was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-b557969252be4ba19752afaa6f5221ef
Source dataset
uspto-grants-2014_07
Patent number
US08778975B2

Reaction notes

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