Sodium Hydroxide → HCID 68468227, compound

HRID 1623589Notes

Reaction equation

HRID 1623589 reaction equation
[CH2:1]([O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][O:15]C(=O)C)[C:9]=1[CH3:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH-].[Na+]>>[CH2:1]([O:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([CH2:14][OH:15])[C:9]=1[CH3:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68468350HCID 68468350, compound

Product 1

HCID 68468227HCID 68468227, compoundYield 87.6%

Procedure

17.3 g (0.065 mol, 1.0 eq.) of 4-hexyloxy-2-acetoxymethyl-3-methylpyridine was added dropwise to a 25% aqueous solution of sodium hydroxide at 5 to 22° C., and the mixture was allowed to react for one hour at room temperature, and then extracted with chloroform. The extract was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 12.7 g of 4-hexyloxy-2-hydroxymethyl-3-methylpyridine as a brown oily matter (yield 87.6%).

Workup

  1. customto react for one hour at room temperature
  2. extractionextracted with chloroform
  3. washThe extract was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-c1a0fb28c9f7407ab97928f289960c4a
Source dataset
uspto-grants-2014_07
Patent number
US08778975B2

Reaction notes

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