Sodium Hydroxide → HCID 68468934, compound

HRID 1623594Notes

Reaction equation

HRID 1623594 reaction equation
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][O:17]C(=O)C)[C:11]=1[CH3:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-].[Na+]>>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][OH:17])[C:11]=1[CH3:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68469851HCID 68469851, compound

Product 1

HCID 68468934HCID 68468934, compoundYield 82.3%

Procedure

17.3 g (0.059 mol, 1.0 eq.) of 4-octyloxy-2-acetoxymethyl-3-methylpyridine was added dropwise to a 25% aqueous solution of sodium hydroxide at 11 to 22° C., and the mixture was allowed to react for one hour at room temperature, and then extracted with chloroform. The extract was washed with water, dried over magnesium sulfate, and then concentrated to dryness, to obtain 12.2 g of 4-octyloxy-2-hydroxymethyl-3-methylpyridine as a pale brown oily matter (yield 82.3%).

Workup

  1. customto react for one hour at room temperature
  2. extractionextracted with chloroform
  3. washThe extract was washed with water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-d09ad4d962b745b0965fad894ae92710
Source dataset
uspto-grants-2014_07
Patent number
US08778975B2

Reaction notes

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