Hydrochloric Acid → 2-Hydroxy-5-(propan-2-yl)benzoic acid

Participants

Reaction Steps

4-Isopropylphenol (2.7 g, 19.83 mmol) and K2CO3 (5.48 g, 39.7 mmol) were heated to 150° C. under an atmosphere of carbon dioxide. The cooled residue was suspended in ethyl acetate and acidified with 2N hydrochloric acid. The organic layer was separated and the combined extracts were dried (MgSO4) and evaporated under reduced pressure to yield the title compound which was used in the next step without further purification. 2.0 g.

Provenance & Evidence