Hydrochloric Acid → 2-Hydroxy-5-(propan-2-yl)benzoic acid

HRID 1623617Notes

Reaction equation

HRID 1623617 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:11]([O-])([O-:13])=[O:12].[K+].[K+].Cl>C(OCC)(=O)C>[OH:10][C:7]1[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][C:6]=1[C:11]([OH:13])=[O:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 74654-IsopropylphenolHCID 11430Potassium Carbonate

Product 1

HCID 125400492-Hydroxy-5-(propan-2-yl)benzoic acid

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4-Isopropylphenol (2.7 g, 19.83 mmol) and K2CO3 (5.48 g, 39.7 mmol) were heated to 150° C. under an atmosphere of carbon dioxide. The cooled residue was suspended in ethyl acetate and acidified with 2N hydrochloric acid. The organic layer was separated and the combined extracts were dried (MgSO4) and evaporated under reduced pressure to yield the title compound which was used in the next step without further purification. 2.0 g.

Workup

  1. customThe organic layer was separated
  2. dry with materialthe combined extracts were dried (MgSO4)
  3. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-d15bd4f26a9a45229c84a821daeca2ff
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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