1-Methylpiperazine → Methyl 2-hydroxy-5-[(4-methyl-1-piperazinyl)sulfonyl]benzoate

Participants

Reaction Steps

Methyl 5-(chlorosulfonyl)-2-hydroxybenzoate (may be prepared as described in Description 60; 500 mg, 1.995 mmol) was added to a stirred solution of 1-methylpiperazine (200 mg, 2.00 mmol) in dichloromethane (20 ml). The mixture was stirred for 0.5 h, and then concentrated under reduced pressure to yield the title compound as a colourless oil. 430 mg.

Provenance & Evidence