1-Methylpiperazine → Methyl 2-hydroxy-5-[(4-methyl-1-piperazinyl)sulfonyl]benzoate

HRID 1623692Notes

Reaction equation

HRID 1623692 reaction equation
Cl[S:2]([C:5]1[CH:6]=[CH:7][C:8]([OH:15])=[C:9]([CH:14]=1)[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>ClCCl>[OH:15][C:8]1[CH:7]=[CH:6][C:5]([S:2]([N:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)(=[O:4])=[O:3])=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 12581955Methyl 5-(chlorosulfonyl)-2-hydroxybenzoate

Product 1

HCID 61061666Methyl 2-hydroxy-5-[(4-methyl-1-piperazinyl)sulfonyl]benzoate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl 5-(chlorosulfonyl)-2-hydroxybenzoate (may be prepared as described in Description 60; 500 mg, 1.995 mmol) was added to a stirred solution of 1-methylpiperazine (200 mg, 2.00 mmol) in dichloromethane (20 ml). The mixture was stirred for 0.5 h, and then concentrated under reduced pressure to yield the title compound as a colourless oil. 430 mg.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-86fb262e9a05481abf164cf1bea8a6d5
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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