反应详情

温度

70 °C

Neat 1-(bromomethyl)-4-fluorobenzene (1533 mg, 8.11 mmol) was added over 1 min to a stirred suspension of 5-bromo-2-hydroxybenzoic acid (800 mg, 3.69 mmol) and potassium carbonate (1274 mg, 9.22 mmol) in acetone (60 ml) in air at room temperature. The reaction mixture was stirred at 70° C. overnight. After filtering, the filtrate was evaporated to give a solid, which was dried in vacuo to yield the title compound as a white solid. 1.56 g.

1. filtrationAfter filtering
2. customthe filtrate was evaporated
3. customto give a solid, which
4. customwas dried in vacuo