HCID 67106787, compound → HCID 67108014, compound

HRID 1623718Notes

Reaction equation

HRID 1623718 reaction equation
C1(C[O:8][C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]\[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][C:10]=2[C:22]([NH:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[O:23])C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][C:10]=1[C:22]([NH:24][C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)=[O:23]

Participants

4

Reactant 1

HCID 67106787HCID 67106787, compound

Product 1

HCID 67108014HCID 67108014, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a suspension of ethyl (2Z)-3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}-2-propenoate (may be prepared as described in Example 68; 160 mg, 0.40 mmol) in methanol (10 ml) was added Pd/C (20 mg). The mixture was put under a hydrogen atmosphere for 5 hours. The catalyst was removed by filtration through Celite and the solvent removed in vacuo to yield the title compound as a pale yellow solid. 119 mg.

Workup

  1. customThe catalyst was removed by filtration through Celite
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-3092405061e048f087271a742b58ab94
Source dataset
uspto-grants-2014_07
Patent number
US08778939B2

Reaction notes

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