反应详情

Iodocyclohexane (29.4 ml, 227 mmol) was added to a solution of 2-(methyloxy)-5-(trifluoromethyl)benzoic acid (5 g, 22.71 mmol) in N,N-dimethylformamide (25 ml), and the mixture was heated under reflux for 4 hours. After cooling, the reaction was evaporated under reduced pressure on a buchi. The residue was triturated with cyclohexane, and the solid obtained was filtered, washed with cyclohexane and dried in air under vacuum. 4.2 g

1. temperaturethe mixture was heated
2. temperatureunder reflux for 4 hours
3. temperatureAfter cooling
4. customthe reaction was evaporated under reduced pressure on a buchi
5. customThe residue was triturated with cyclohexane
6. customthe solid obtained
7. filtrationwas filtered
8. washwashed with cyclohexane
9. customdried in air under vacuum