反应详情

温度

90 °C

A mixture of methyl {3-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetate (may be prepared as described in Description 46, 160 mg, 0.39 mmol), 2M HCl (3 ml) and acetic acid (3 ml) was heated at 90° C. for 4 hours and then cooled to room temperature. Water was added and the mixture was filtered to give a white solid. The crude product was purified by MDAP to yield the title compound as a white solid. 53 mg.

1. temperaturecooled to room temperature
2. filtrationthe mixture was filtered
3. customto give a white solid
4. customThe crude product was purified by MDAP