2-Amino-2-methyl-1-propanol → HCID 86669657, compound

HRID 1623907Notes

Reaction equation

HRID 1623907 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[N:4]=[CH:5][C:6]([N:9]2[C:16]3[C@@H:15]4[CH2:17][C@@H:14]4[CH2:13][C:12]=3[C:11]([C:18](O)=[O:19])=[N:10]2)=[N:7][CH:8]=1.[NH2:23][C:24]([CH3:28])([CH3:27])[CH2:25][OH:26]>>[OH:26][CH2:25][C:24]([NH:23][C:18]([C:11]1[C:12]2[CH2:13][C@H:14]3[CH2:17][C@H:15]3[C:16]=2[N:9]([C:6]2[CH:5]=[N:4][C:3]([C:2]([F:22])([F:21])[F:1])=[CH:8][N:7]=2)[N:10]=1)=[O:19])([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 68182480HCID 68182480, compound

Product 1

HCID 86669657HCID 86669657, compound

Procedure

The title compound was prepared in a manner similar to that described in Method G, using (1aR,5aR)-2-(5-trifluoromethylpyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid and 2-amino-2-methylpropan-1-ol. LCMS m/z=382.2 [M+H]+; 1H NMR (400 MHz, CDCl3) δ ppm 0.47 (td, J=4.3, 4.0 Hz, 1H), 1.28 (td, J=7.8, 5.2 Hz, 1H), 1.49 (s, 6H), 2.30-2.36 (m, 1H), 2.74-2.78 (m, 1H), 2.93 (d, J=16.8 Hz, 1H), 3.02 (dd, J=16.6, 6.2 Hz, 1H), 3.71 (s, 2H), 4.43 (bs, 1H), 6.94 (s, 1H), 8.77 (s, 1H), 9.32 (s, 1H).

Sources & evidence

ORD record
ord-d1a8fb24a51f440cb6108b5daa6477e0
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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