2-Amino-2-methyl-1-propanol → HCID 86669689, compound

HRID 1623950Notes

Reaction equation

HRID 1623950 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([N:9]2[C:16]3[C@@H:15]4[CH2:17][C@@H:14]4[CH2:13][C:12]=3[C:11]([C:18]([OH:20])=O)=[N:10]2)=[N:7][CH:8]=1.[NH2:21][C:22]([CH3:26])([CH3:25])[CH2:23][OH:24]>>[OH:24][CH2:23][C:22]([NH:21][C:18]([C:11]1[C:12]2[CH2:13][C@H:14]3[CH2:17][C@H:15]3[C:16]=2[N:9]([C:6]2[CH:5]=[N:4][C:3]([O:2][CH3:1])=[CH:8][N:7]=2)[N:10]=1)=[O:20])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 68182434HCID 68182434, compound

Product 1

HCID 86669689HCID 86669689, compound

Procedure

The title compound was prepared in a manner similar to that described in Method RR using (1aR,5aR)-2-(5-methoxypyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid and 2-amino-2-methylpropan-1-ol. LCMS m/z=344.3 [M+H]+; 1H NMR (400 MHz, CDCl3) δ ppm 0.44 (td, J=4.6 and 3.4 Hz, 1H), 1.18-1.22 (m, 1H), 1.39 (s, 3H), 1.40 (s, 3H), 2.23-2.28 (m, 1H), 2.62-2.67 (m, 1H), 2.88 (d, J=16.8 Hz, 1H), 2.97 (dd, J=16.5 and 6.3 Hz, 1H), 3.68 (s, 2H), 4.01 (s, 3H), 4.17 (br, 1H), 6.96 (s, 1H), 8.05 (d, J=1.4 Hz, 1H), 8.67 (d, J=1.4 Hz, 1H).

Sources & evidence

ORD record
ord-8da17814f69941418b816b51e4efadee
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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