2-Amino-2-methyl-1-propanol → HCID 86669697, compound

HRID 1623959Notes

Reaction equation

HRID 1623959 reaction equation
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[F:7][C:8]([F:31])([C:13]1[N:14]=[CH:15][C:16]([N:19]2[C:26]3[C@@H:25]4[CH2:27][C@@H:24]4[CH2:23][C:22]=3[C:21]([C:28](O)=[O:29])=[N:20]2)=[N:17][CH:18]=1)[C:9]([F:12])([F:11])[F:10]>>[OH:4][CH2:3][C:2]([NH:1][C:28]([C:21]1[C:22]2[CH2:23][C@H:24]3[CH2:27][C@H:25]3[C:26]=2[N:19]([C:16]2[CH:15]=[N:14][C:13]([C:8]([F:7])([F:31])[C:9]([F:12])([F:10])[F:11])=[CH:18][N:17]=2)[N:20]=1)=[O:29])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 86669698HCID 86669698, compound

Product 1

HCID 86669697HCID 86669697, compound

Procedure

The title compound was prepared in a manner similar to that described in Method G, using 2-amino-2-methylpropan-1-ol and (1aR,5aR)-2-(5-(perfluoroethyl)pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid. LCMS m/z=432.3 [M+H]+; 1H NMR (400 MHz, CDCl3) δ ppm 0.47 (td, J=4.7, 3.3 Hz, 1H), 1.29 (td, J=8.0, 4.9 Hz, 1H), 1.42 (s, 6H), 2.30-2.37 (m, 1H), 2.75-2.79 (m, 1H), 2.93 (d, J=16.9 Hz, 1H), 3.02 (dd, J=16.7, 6.3 Hz, 1H), 3.71 (d, J=6.1 Hz, 2H), 4.40 (d, J=6.1 Hz, 1H), 6.93 (s, 1H), 8.78 (d, J=1.3 Hz, 1H), 9.35 (d, J=1.0 Hz, 1H).

Sources & evidence

ORD record
ord-e0c77f5717064cee855212e028a0c4e9
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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