Hydrochloric Acid → HCID 67060892, compound

HRID 1623985Notes

Reaction equation

HRID 1623985 reaction equation
CC(S([NH:7][C:8]1([C:12]([F:15])([F:14])[F:13])[CH2:11][O:10][CH2:9]1)=O)(C)C.[ClH:16].O1CCOCC1>CO>[ClH:16].[F:13][C:12]([F:15])([F:14])[C:8]1([NH2:7])[CH2:11][O:10][CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67060889HCID 67060889, compound

Product 1

HCID 67060892HCID 67060892, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Methyl-N-(3-(trifluoromethyl)oxetan-3-yl)propane-2-sulfinamide (52 mg, 0.212 mmol) was dissolved in methanol (1 mL). The solution was cooled down at ice-water bath and added slowly 4 N HCl in dioxane (240 μL, 0.954 mmol). The mixture was warmed to room temperature, stirred for 5 h, then concentrated. The solid was washed with ether twice then dried in vacuo to give the title compound (27 mg).

Workup

  1. temperatureThe solution was cooled down at ice-water bath
  2. concentrationconcentrated
  3. washThe solid was washed with ether twice
  4. customdried in vacuo

Sources & evidence

ORD record
ord-c16a79f79d9e4ea881bdbe298dd8ece0
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

Loading…