反应详情

温度

23 °C

To a solution of (1aS,5aS)-2-(4-bromo-pyridin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ethyl ester (1.00 g, 2.87 mmol) in methanol (5 mL) and THF (5.00 mL) was added a 2.0 M aqueous solution of sodium hydroxide (2.87 mL, 5.74 mmol). The reaction was stirred at 23° C. for 2 h. The organic solvents were removed by distillation. The remaining aqueous solution was diluted with water (20 mL) then acidified to pH ˜2 by addition of 6 M aq. HCl. The resulting precipitate was collected by filtration, rinsed with water, then dried under vacuum to give the title compound (0.87 g) as a white solid. LCMS m/z=320.0 [M+H]+.

1. customThe organic solvents were removed by distillation
2. additionThe remaining aqueous solution was diluted with water (20 mL)
3. additionthen acidified to pH ˜2 by addition of 6 M aq. HCl
4. filtrationThe resulting precipitate was collected by filtration
5. washrinsed with water
6. customdried under vacuum