反应详情

350 mg of 10% palladium/carbon were added to a solution of 3.5 g (9.18 mmol) of 8-(benzyloxy)-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide in 250 ml of ethyl acetate, and hydrogen was applied at room temperature and atmospheric pressure. After 3 h, the mixture was filtered off through kieselguhr, the filter cake was washed intensively with ethyl acetate/methanol and the filtrate was evaporated to dryness. Methyl tert-butyl ether was added to the crude product obtained, the product was triturated and the solid was then filtered off and dried at 40° C. under high vacuum. This gave 2.1 g (79% of theory) of 8-hydroxy-N-[(2R)-1-hydroxyhexan-2-yl]-2-methylimidazo[1,2-a]pyridine-3-carboxamide

1. customwas applied at room temperature
2. filtrationthe mixture was filtered off through kieselguhr
3. washthe filter cake was washed intensively with ethyl acetate/methanol
4. customthe filtrate was evaporated to dryness
5. additionMethyl tert-butyl ether was added to the crude product
6. customobtained
7. customthe product was triturated
8. filtrationthe solid was then filtered off
9. customdried at 40° C. under high vacuum