Dimethylformamide → HCID 74222519, compound

HRID 1624102Notes

Reaction equation

HRID 1624102 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:12]([C:16](O)=[O:17])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.CN([CH:27]=[O:28])C>ClCCl>[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:12]([C:16]([NH:14][CH2:13][CH2:12][C:16]([O:28][CH3:27])=[O:17])=[O:17])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 867178728-((2,6-Difluorobenzyl)oxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

Product 1

HCID 74222519HCID 74222519, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The example compounds shown in Table 6A were prepared analogously to Example Compound 78A by reacting 8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid with the appropriate commercially available amines in DMF or dichloromethane under the reaction conditions described in the Representative Working Procedure 2a:

Workup

  1. customunder the reaction conditions

Sources & evidence

ORD record
ord-96e74038c9434862ad5d8d3a49f4cf68
Source dataset
uspto-grants-2014_07
Patent number
US08778964B2

Reaction notes

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