Thioacetamide → HCID 86675538, compound

Participants

Reaction Conditions

Reaction Steps

5 mmol of ethyl 4-(bromomethyl)-2-methyl-1,3-thiazole-5-carboxylate was dissolved in 50 ml of ethanol, then 5.5 mmol of thioacetoamide was added, and the temperature was heated up to 95° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature. Ethanol was evaporated out and then purification was carried out using column separation method with solvents of ethylacetate and hexane, obtaining ethyl 4-(mercaptomethyl)-2-methyl-1,3-thiazole-5-carboxylate.

Provenance & Evidence