Thioacetamide → HCID 86675538, compound

HRID 1624215Notes

Reaction equation

HRID 1624215 reaction equation
Br[CH2:2][C:3]1[N:4]=[C:5]([CH3:13])[S:6][C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].C(N)(=[S:16])C>C(O)C>[SH:16][CH2:2][C:3]1[N:4]=[C:5]([CH3:13])[S:6][C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

4

Reactant 2

HCID 2723949ThioacetamideHCID 20491757HCID 20491757, compound

Product 1

HCID 86675538HCID 86675538, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
95 °C

Procedure

5 mmol of ethyl 4-(bromomethyl)-2-methyl-1,3-thiazole-5-carboxylate was dissolved in 50 ml of ethanol, then 5.5 mmol of thioacetoamide was added, and the temperature was heated up to 95° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature. Ethanol was evaporated out and then purification was carried out using column separation method with solvents of ethylacetate and hexane, obtaining ethyl 4-(mercaptomethyl)-2-methyl-1,3-thiazole-5-carboxylate.

Workup

  1. customthe reaction for 4 hours
  2. temperatureThe reacted liquid was cooled down to a room temperature
  3. customEthanol was evaporated out
  4. custompurification
  5. customcolumn separation method with solvents of ethylacetate and hexane

Sources & evidence

ORD record
ord-aa8691cf92424983a6a7a54130939238
Source dataset
uspto-grants-2014_07
Patent number
US08779086B2

Reaction notes

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