Acetic Acid → HCID 9812833, compound

HRID 1624217Notes

Reaction equation

HRID 1624217 reaction equation
[SH:1][CH2:2][C:3]1[N:4]=[C:5]([CH3:10])[S:6][C:7]=1[CH:8]=O.C(O)(=O)C>C(O)C>[CH3:10][C:5]1[S:6][C:7]2[C:3](=[CH:2][S:1][CH:8]=2)[N:4]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 86675539HCID 86675539, compound

Product 1

HCID 9812833HCID 9812833, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

5 mmol of 4-(mercaptomethyl)-2-methyl-1,3-thiazole-5-carbaldehyde was dissolved in 50 ml of ethanol, then 50 mmol of acetic acid was added, and stirring was continued for 1 hour at a room temperature. Then the temperature was heated up to 80° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature. The solvent was evaporated out and then purification was carried out using column separation with solvents of ethylacetate and hexane, obtaining 2-methylthieno[3,4-d][1,3]thiazole.

Workup

  1. customthe reaction for 4 hours
  2. temperatureThe reacted liquid was cooled down to a room temperature
  3. customThe solvent was evaporated out
  4. custompurification
  5. customcolumn separation with solvents of ethylacetate and hexane

Sources & evidence

ORD record
ord-3da86ecd216f40d2973adc4896dc26bd
Source dataset
uspto-grants-2014_07
Patent number
US08779086B2

Reaction notes

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