Acetic Acid → HCID 9812833, compound

Participants

Reaction Conditions

Reaction Steps

5 mmol of 4-(mercaptomethyl)-2-methyl-1,3-thiazole-5-carbaldehyde was dissolved in 50 ml of ethanol, then 50 mmol of acetic acid was added, and stirring was continued for 1 hour at a room temperature. Then the temperature was heated up to 80° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature. The solvent was evaporated out and then purification was carried out using column separation with solvents of ethylacetate and hexane, obtaining 2-methylthieno[3,4-d][1,3]thiazole.

Provenance & Evidence