Thioacetamide → Ethyl 4-(mercaptomethyl)-2-methyl-1,3-oxazole-5-carboxylate

Participants

Reaction Conditions

Reaction Steps

5 mmol of ethyl 4-(bromomethyl)-2-methyl-1,3-oxazole-5-carboxylate was dissolved in 50 ml of ethanol, then 5.5 mmol of thioacetoamide was added, then heated up to 90° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature. Ethanol is evaporated out and then the product was purified using column separation with solvents of ethyl acetate and hexane, obtaining ethyl 4-(mercaptomethyl)-2-methyl-1,3-oxazole-5-carboxylate (yield 95%).

Provenance & Evidence