反应详情

温度

90 °C

5 mmol of ethyl 4-(bromomethyl)-2-methyl-1,3-oxazole-5-carboxylate was dissolved in 50 ml of ethanol, then 5.5 mmol of thioacetoamide was added, then heated up to 90° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature. Ethanol is evaporated out and then the product was purified using column separation with solvents of ethyl acetate and hexane, obtaining ethyl 4-(mercaptomethyl)-2-methyl-1,3-oxazole-5-carboxylate (yield 95%).

1. customthe reaction for 4 hours
2. temperatureThe reacted liquid was cooled down to a room temperature
3. customEthanol is evaporated out
4. customthe product was purified
5. customcolumn separation with solvents of ethyl acetate and hexane