2,6-Dibromopyridine → 2-Bromo-6-(4-fluoro-benzyl)-pyridine

HRID 1624465Notes

Reaction equation

HRID 1624465 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[Br-].[F:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][Zn+])=[CH:13][CH:12]=1>>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH2:15][C:14]2[CH:17]=[CH:18][C:11]([F:10])=[CH:12][CH:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 122742,6-DibromopyridineHCID 178505763HCID 178505763, compound

Product 1

HCID 541476392-Bromo-6-(4-fluoro-benzyl)-pyridine

Procedure

Prepared according to the procedure described in Example 53, Step 2, using 2,6-dibromo-pyridine and 4-fluoro-benzylzinc bromide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-193e86d8891341429bb922f2517fada4
Source dataset
uspto-grants-2014_07
Patent number
US08778983B2

Reaction notes

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