Ethyl chloroformate → HCID 86715999, compound

HRID 1624859Notes

Reaction equation

HRID 1624859 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].Cl.[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[CH:14]([NH2:20])[CH2:13]2>C(N(CC)CC)C.ClCCl>[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[CH:14]([NH:20][C:2](=[O:3])[O:4][CH2:5][CH3:6])[CH2:13]2

Participants

5

Reactant 2

HCID 10928Ethyl chloroformateHCID 86716000HCID 86716000, compound

Product 1

HCID 86715999HCID 86715999, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

1.5 mL of ethyl chloroformate are poured into a suspension of 3.4 g of the compound obtained in Step 1 in 4.5 mL of triethylamine and 50 mL of dichloromethane and left overnight, whilst stiffing at ambient temperature; washing with water and with 1N hydrochloric acid is then carried out. Drying is carried out and the solvent is evaporated off to dryness. 3.2 g of an oil corresponding to the expected product are obtained.

Workup

  1. customwhilst stiffing at ambient temperature
  2. washwashing with water and with 1N hydrochloric acid
  3. customDrying
  4. customthe solvent is evaporated off to dryness

Sources & evidence

ORD record
ord-a5293d8f535b47968d9ea89153a9ec33
Source dataset
uspto-grants-2014_07
Patent number
US08779121B2

Reaction notes

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