HCID 11844929, compound → HCID 11844928, compound

HRID 1624977Notes

Reaction equation

HRID 1624977 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]([C:11]2[C:12]3[CH2:20][CH2:19][N:18](CC4C=CC=CC=4)[CH2:17][C:13]=3[N:14]=[CH:15][N:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>[Pd]>[CH:1]1([CH2:7][NH:8][C:9]([C:11]2[C:12]3[CH2:20][CH2:19][NH:18][CH2:17][C:13]=3[N:14]=[CH:15][N:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 11844929HCID 11844929, compound

Product 1

HCID 11844928HCID 11844928, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Into a 500 ml hydrogenation vessel was combined 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-carboxylic acid, cyclohexylmethyl-amide (80 mg, 0.22 mmol), palladium on carbon (30 mg) and methano. The vessel was purged and evacuated with hydrogen three times and allowed to agitate overnight at 15 psi. The contents were filtered over celite and concentrated to afford the title compound (4.7 mg, 7.7%.

Workup

  1. customInto a 500 ml hydrogenation vessel was combined
  2. customThe vessel was purged
  3. customevacuated with hydrogen three times
  4. filtrationThe contents were filtered over celite and
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-be3167e02d4b43e88492a5f69cdbc54e
Source dataset
uspto-grants-2014_07
Patent number
US08779144B2

Reaction notes

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