HCID 11844929, compound → HCID 11844928, compound

Participants

Reaction Steps

Into a 500 ml hydrogenation vessel was combined 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-4-carboxylic acid, cyclohexylmethyl-amide (80 mg, 0.22 mmol), palladium on carbon (30 mg) and methano. The vessel was purged and evacuated with hydrogen three times and allowed to agitate overnight at 15 psi. The contents were filtered over celite and concentrated to afford the title compound (4.7 mg, 7.7%.

Provenance & Evidence