Phosphoric Acid → HCID 178434041, compound

HRID 1625095Notes

Reaction equation

HRID 1625095 reaction equation
[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28]4)=[O:26])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>C(OCC)(=O)C>[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:28][CH2:29][C:30]([F:34])([F:33])[CH2:31][CH2:32]4)=[O:26])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38]([O-:42])([O-:41])([O-:40])=[O:39]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178434039HCID 178434039, compound

Product 1

HCID 178434041HCID 178434041, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Maraviroc (10 gm) was dissolved in ethyl acetate (100 ml) and stirred for 30 minutes at room temperature. To the solution was added phosphoric acid (2 gm) and stirred for 11 hours at room temperature, filtered. The solid obtained was dried to obtain 11 gm of crystalline form 2 of maraviroc phosphate.

Workup

  1. stirringstirred for 11 hours at room temperature
  2. filtrationfiltered
  3. customThe solid obtained
  4. customwas dried

Sources & evidence

ORD record
ord-c90c9ef0718b482f9df66c0b3f895577
Source dataset
uspto-grants-2014_07
Patent number
US08779143B2

Reaction notes

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