Phosphoric Acid → HCID 178434041, compound

HRID 1625096Notes

Reaction equation

HRID 1625096 reaction equation
[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28]4)=[O:26])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>C(O)(C)C>[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:28][CH2:29][C:30]([F:34])([F:33])[CH2:31][CH2:32]4)=[O:26])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38]([O-:42])([O-:41])([O-:40])=[O:39]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178434039HCID 178434039, compound

Product 1

HCID 178434041HCID 178434041, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Maraviroc (10 gm) was dissolved in isopropyl alcohol (100 ml) and stirred for 30 minutes at room temperature. To the solution was added phosphoric acid (2 gm) and stirred for 11 hours at room temperature. The solid obtained was collected by filtration and dried to obtain 10.5 gm of crystalline form 3 of maraviroc phosphate.

Workup

  1. stirringstirred for 11 hours at room temperature
  2. customThe solid obtained
  3. filtrationwas collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-548a0925bd934ada8c9ced971447086a
Source dataset
uspto-grants-2014_07
Patent number
US08779143B2

Reaction notes

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