Phosphoric Acid → HCID 178434041, compound

HRID 1625098Notes

Reaction equation

HRID 1625098 reaction equation
[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28]4)=[O:26])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>C(O)C>[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:28][CH2:29][C:30]([F:34])([F:33])[CH2:31][CH2:32]4)=[O:26])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38]([O-:42])([O-:41])([O-:40])=[O:39]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178434039HCID 178434039, compound

Product 1

HCID 178434041HCID 178434041, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Maraviroc (100 gm) was dissolved in ethanol (100 ml) and stirred for 30 minutes at room temperature. To the solution was added phosphoric acid (2 gm) and then cooled to 0 to 5° C. The reaction mass was stirred for 12 hours at 0 to 5° C. and filtered. The solid obtained was dried to obtain 98 gm of crystalline form 4 of maraviroc phosphate.

Workup

  1. temperaturecooled to 0 to 5° C
  2. stirringThe reaction mass was stirred for 12 hours at 0 to 5° C.
  3. filtrationfiltered
  4. customThe solid obtained
  5. customwas dried

Sources & evidence

ORD record
ord-c89daae779d441918560fdb269225f9c
Source dataset
uspto-grants-2014_07
Patent number
US08779143B2

Reaction notes

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