反应详情

Compound (154d) (2.20 g) was dissolved in chloroform (14 mL), and thionyl chloride (1.00 mL) and DMF (0.148 mL) were added to the resulting solution, followed by reflux for 3 hr. Water was added to the reaction solution for distribution. The organic layer was washed with saturated sodium bicarbonate water. The organic layer after the washing was dried over anhydrous sodium sulfate, and the solvent was distilled away. 2-Propanol was added to the residue, and the precipitate was collected by filtration and then dried under reduced pressure to obtain compound (154e) (1.60 g, 71%).

1. temperatureby reflux for 3 hr
2. washThe organic layer was washed with saturated sodium bicarbonate water
3. dry with materialThe organic layer after the washing was dried over anhydrous sodium sulfate
4. distillationthe solvent was distilled away
5. addition2-Propanol was added to the residue
6. filtrationthe precipitate was collected by filtration
7. customdried under reduced pressure