Hydrochloric Acid → HCID 68606159, compound

HRID 1625435Notes

Reaction equation

HRID 1625435 reaction equation
[C:1]1([S:7]([N:10]2[C:14]3=[N:15][CH:16]=[C:17]([C:19](C)(C)[O:20][SiH2]C(C)(C)C)[CH:18]=[C:13]3[C:12]([C:28]3[CH:29]=[C:30]([CH:51]=[CH:52][CH:53]=3)[CH2:31][NH:32][C:33]([C:35]3[C:36](=[O:50])[N:37]([CH2:41][C:42]4[CH:47]=[CH:46][C:45]([F:48])=[C:44]([F:49])[CH:43]=4)[CH:38]=[CH:39][CH:40]=3)=[O:34])=[CH:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.O>C(O)C>[C:1]1([S:7]([N:10]2[C:14]3=[N:15][CH:16]=[C:17]([CH2:19][OH:20])[CH:18]=[C:13]3[C:12]([C:28]3[CH:29]=[C:30]([CH:51]=[CH:52][CH:53]=3)[CH2:31][NH:32][C:33]([C:35]3[C:36](=[O:50])[N:37]([CH2:41][C:42]4[CH:47]=[CH:46][C:45]([F:48])=[C:44]([F:49])[CH:43]=4)[CH:38]=[CH:39][CH:40]=3)=[O:34])=[CH:11]2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 178455439HCID 178455439, compound

Product 1

HCID 68606159HCID 68606159, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into a 1-neck round-bottom flask was dissolved 1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 3-[1-benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-benzylamide (0.17 mmol, 0.00017 mol) in ethanol (3.00 mL, Fisher;). To this was added 12 M of hydrogen chloride in water (1.00 mL, 0.012 mol; Fisher) and the reaction was stirred at room temperature for 1 h and then evaporated to give the crude product.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-3e546faf08a641799a0b60d6a1c27180
Source dataset
uspto-grants-2014_07
Patent number
US08778977B2

Reaction notes

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