HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid | HCID 53427969 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride | HCID 59362335 | — |
Reaction Steps
The flask was charged with dichloromethane, 20 mg of 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, DMF, (COCl)2 was added slowly via syringe. Then the resulted mixture was allowed to stir at room temperature for 3 h. After TLC show the reaction was complete, the solvent was removed under high vacuum to give 25 mg of crude product, which was used for the next step reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08778977B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-f43a7b016f0d4e24bf5199748fb79bbc |
| Source note | uspto-grants-2014_07 |