Methylamine → HCID 86642423, compound

HRID 1625489Notes

Reaction equation

HRID 1625489 reaction equation
Br[C:2]1[N:3]=[C:4]([Br:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[CH3:12][NH2:13]>>[Br:11][C:4]1[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=[C:2]([NH:13][CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

Product 1

HCID 86642423HCID 86642423, compoundYield 96%

Procedure

A mixture of 100 mg (0.36 mmol) of 6.8-dibromoimidazo[1,2-a]pyrazine in 5 ml of a 25% aqueous methylamine solution was stirred for 12 h. After the removal of solvent, the residue was purified by chromatography (silica column eluted with ether) to provide 78 mg (yield: 96%) of 8-bromo-6-methylaminoimidazo[1,2-a]pyrazine. ESI-MS (M+H+): 227.

Workup

  1. customAfter the removal of solvent
  2. customthe residue was purified by chromatography (silica column eluted with ether)

Sources & evidence

ORD record
ord-4668fc1331e64b87b978dbc0f3081be0
Source dataset
uspto-grants-2014_07
Patent number
US08778977B2

Reaction notes

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