Hydrochloric Acid → HCID 178502120, compound

HRID 1625492Notes

Reaction equation

HRID 1625492 reaction equation
C(OC([N:8]1[CH2:12][C@@H:11]([CH3:13])[CH2:10][C@H:9]1[C:14]1[NH:15][CH:16]=[C:17]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:57]=[CH:56][C:34]5[NH:35][C:36]([C@@H:38]6[CH2:42][C@H:41]([CH3:43])[CH2:40][N:39]6[C:44](=[O:55])[C@@H:45]([N:49]([C:51]([O:53][CH3:54])=[O:52])[CH3:50])[CH:46]([CH3:48])[CH3:47])=[N:37][C:33]=5[CH:32]=4)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[N:18]=1)=O)(C)(C)C.[ClH:58].O1CCOCC1>CO>[ClH:58].[CH3:54][O:53][C:51](=[O:52])[N:49]([CH3:50])[C@H:45]([C:44]([N:39]1[CH2:40][C@@H:41]([CH3:43])[CH2:42][C@H:38]1[C:36]1[NH:35][C:34]2[CH:56]=[CH:57][C:31]([C:28]3[CH:29]=[CH:30][C:25]([C:22]4[CH:23]=[CH:24][C:19]([C:17]5[N:18]=[C:14]([C@@H:9]6[CH2:10][C@H:11]([CH3:13])[CH2:12][NH:8]6)[NH:15][CH:16]=5)=[CH:20][CH:21]=4)=[CH:26][CH:27]=3)=[CH:32][C:33]=2[N:37]=1)=[O:55])[CH:46]([CH3:48])[CH3:47]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178502119HCID 178502119, compound

Product 1

HCID 178502120HCID 178502120, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (2S,4S)-2-{4-[4′-(2-{(2S,4S)-1-[(S)-2-(methoxycarbonyl-methyl-amino)-3-methyl-butyryl]-4-methyl-pyrrolidin-2-yl}-1H-benzoimidazol-5-yl)-biphenyl-4-yl]-1H-imidazol-2-yl}-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester (115 mg, 0.1486 mmol) in methanol is added 4M HCl in dioxane (0.632 mL, 2.526 mmol). The reaction mixture is stirred at room temperature for 1 hour and concentrated to dryness. The title product is used as such in the next step.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-f76fc4e64eb0496fb026fcbaa4c6239d
Source dataset
uspto-grants-2014_07
Patent number
US08779156B2

Reaction notes

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