Hydrochloric Acid → HCID 178461569, compound

Participants

Reaction Conditions

Reaction Steps

In a 100 mL flask, (2S,4S)-tert-butyl 2-(6-(4′-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1′-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate (2.55 g, 3.628 mmol) is dissolved in CH2Cl2 (10 mL). The solution is cooled to 0° C. and HCl (18.14 mL of 2.0 M, 36.28 mmol) is added. The reaction mixture is then stirred vigorously for 30 min at rt. The solution is concentrated and then dried under high vacuum. The yellow salt (2.353 g) is used in the next reaction without further purification.

Provenance & Evidence