Hydrochloric Acid → HCID 178461569, compound

HRID 1625497Notes

Reaction equation

HRID 1625497 reaction equation
C(OC([N:8]1[CH2:12][C@@H:11]([CH3:13])[CH2:10][C@H:9]1[C:14]1[NH:15][CH:16]=[C:17]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:32]=[CH:33][C:34]5[NH:38][C:37]([C@@H:39]6[CH2:43][C@H:42]([CH3:44])[CH2:41][N:40]6C(OC(C)(C)C)=O)=[N:36][C:35]=5[CH:52]=4)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[N:18]=1)=O)(C)(C)C.Cl>C(Cl)Cl>[CH3:44][C@@H:42]1[CH2:41][NH:40][C@H:39]([C:37]2[NH:38][C:34]3[CH:33]=[CH:32][C:31]([C:28]4[CH:27]=[CH:26][C:25]([C:22]5[CH:21]=[CH:20][C:19]([C:17]6[N:18]=[C:14]([C@@H:9]7[CH2:10][C@H:11]([CH3:13])[CH2:12][NH:8]7)[NH:15][CH:16]=6)=[CH:24][CH:23]=5)=[CH:30][CH:29]=4)=[CH:52][C:35]=3[N:36]=2)[CH2:43]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178461447HCID 178461447, compound

Product 1

HCID 178461569HCID 178461569, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

In a 100 mL flask, (2S,4S)-tert-butyl 2-(6-(4′-(2-((2S,4S)-1-(tert-butoxycarbonyl)-4-methylpyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1′-biphenyl]-4-yl)-3H-benzo[d]imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate (2.55 g, 3.628 mmol) is dissolved in CH2Cl2 (10 mL). The solution is cooled to 0° C. and HCl (18.14 mL of 2.0 M, 36.28 mmol) is added. The reaction mixture is then stirred vigorously for 30 min at rt. The solution is concentrated and then dried under high vacuum. The yellow salt (2.353 g) is used in the next reaction without further purification.

Workup

  1. concentrationThe solution is concentrated
  2. customdried under high vacuum
  3. customThe yellow salt (2.353 g) is used in the next reaction without further purification

Sources & evidence

ORD record
ord-c12d8ee095664eda883d4befc1fd1ceb
Source dataset
uspto-grants-2014_07
Patent number
US08779156B2

Reaction notes

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