反应详情

To a solution of tert-butyl (2S,4S)-4-methyl-2-[4-[4-(2-trimethylsilylethynyl)phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate (57 mg, 0.1346 mmol) in MeOH (2 mL) is added K2CO3 (37.2 mg, 0.27 mmol). The mixture is stirred at rt for 2 hours. After removal of the solvent under reduced pressure, the residue is purified by flash column chromatography on silica gel using 0-5% MeOH/CH2Cl2 to provide tert-butyl (2S,4S)-2-[4-(4-ethynylphenyl)-1H-imidazol-2-yl]-4-methyl-pyrrolidine-1-carboxylate (47 mg, 99%).

1. customAfter removal of the solvent under reduced pressure
2. customthe residue is purified by flash column chromatography on silica gel using 0-5% MeOH/CH2Cl2