2-(Bromomethyl)pyridine hydrobromide → HCID 57330882, compound

HRID 1625558Notes

Reaction equation

HRID 1625558 reaction equation
[CH3:1][C:2]1[O:3][C:4]([CH3:13])=[CH:5][C:6]=1[C:7]1[NH:8][C:9](=[S:12])[NH:10][N:11]=1.Br.Br[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[CH3:1][C:2]1[O:3][C:4]([CH3:13])=[CH:5][C:6]=1[C:7]1[NH:11][N:10]=[C:9]([S:12][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[N:8]=1

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178423531HCID 178423531, compound

Product 1

HCID 57330882HCID 57330882, compoundYield 70%

Procedure

Prepared in a similar manner to example 1 using 5-(2,5-dimethylfuran-3-yl)-2H-1,2,4-triazole-3(4H)-thione (example 7a) and 2-(bromomethyl)pyridine hydrobromide. Yield 70%. 1H NMR (500 MHz, CDCl3): δ 2.27 (s, 3H), 2.59 (s, 3H), 4.32 (s, 2H), 6.35 (s, 1H), 7.28-7.29 (d, 1H), 7.35-7.36 (d, 1H), 7.75 (t, 1H) 8.62 (s, 1H). MS (M+H, 287).

Sources & evidence

ORD record
ord-ee4c4859c0e74ab2a971fbf76d970449
Source dataset
uspto-grants-2014_07
Patent number
US08784782B2

Reaction notes

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