反应详情

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

1. temperaturewas refluxed overnight
2. customMeOH was evaporated
3. extractionthe residue was extracted to EtOAc
4. washsuccessively washed with water and brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated