HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-chloro-2-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Chloro-o-anisic acid | HCID 93682 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | Methyl 4-chloro-2-methoxybenzoate | HCID 327084 | 96% |
Reaction Steps
A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08784782B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-35683c0c1bac4d0186e085f4d11a2c02 |
| Source note | uspto-grants-2014_07 |