HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [4'-(6-Ethoxy-pyridin-3-yl)-2'-ethylaminomethyl-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | [2'-[(tert-Butoxycarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester | HCID 58149276 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [4'-(6-Ethoxy-pyridin-3-yl)-2'-ethylaminomethyl-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester hydrochloride | HCID 66958971 | — |
Reaction Steps
[2′-[(tert-Butoxycarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester (0.404 g, 0.736 mmol) in dichloromethane (3 mL) was treated with 4N hydrochloric acid in 1,4-dioxane (2.5 mL, 10 mmol) at room temperature, until complete conversion was seen by analytical LCMS. The mixture was concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785393B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-e4c2350ec5eb44f2be3a54da5a5bef21 |
| Source note | uspto-grants-2014_07 |