Lithium Hydroxide → HCID 58481210, compound

HRID 1625701Notes

Reaction equation

HRID 1625701 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH2:11][CH2:12][C:13]([O:15]C)=[O:14])[CH:7]=[CH:8][C:9]=1[NH2:10])(=[O:3])[CH3:2].[Li+:17].[OH-]>C1COCC1.O>[C:1]([C:4]1[CH:5]=[C:6]([CH2:11][CH2:12][C:13]([O-:15])=[O:14])[CH:7]=[CH:8][C:9]=1[NH2:10])(=[O:3])[CH3:2].[Li+:17]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 58481117HCID 58481117, compound

Product 1

HCID 58481210HCID 58481210, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

Methyl 3-(3-acetyl-4-aminophenyl)propanoate (221 mg) and 4 M LiOH (0.275 mL) were added to 3 mL THF/water(v/v=3/1). The solvent was removed under reduced pressure after the reaction completed, affording lithium 3-(3-acetyl-4-aminophenyl)propanoate (X3547-1). 1H NMR (400 MHz, MeOD): δ 7.62 (d, J=2.0 Hz, 1H), 7.17 (dd, J=8.4 Hz, J′=2.0 Hz, 1H), 6.67 (d, J=8.4 Hz, 1H), 2.80 (dd, J=7.6 Hz, J′=9.0 Hz, 2H), 2.55 (s, 3H), 2.41 (dd, J=7.6 Hz, J′=9.0 Hz, 2H); MS-ESI+ 207.22 (MH+).

Workup

  1. customThe solvent was removed under reduced pressure after the reaction

Sources & evidence

ORD record
ord-77882a73180145efb3a429c01e85c6c5
Source dataset
uspto-grants-2014_07
Patent number
US08785151B2

Reaction notes

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