Lithium Hydroxide → HCID 58481158, compound

HRID 1625704Notes

Reaction equation

HRID 1625704 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15])[CH:5]=[CH:6][C:7]=1[CH:8]=[O:9].[Li+:18].[OH-]>C1COCC1.O>[NH2:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O-:16])=[O:15])[CH:5]=[CH:6][C:7]=1[CH:8]=[O:9].[Li+:18]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 58481179HCID 58481179, compound

Product 1

HCID 58481158HCID 58481158, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

Methyl 5-(3-amino-4-formylphenyl)pentanoate (447 mg) was treated with LiOH (88 mg) in 8.0 mL THF/water(v/v=3/1). Removal of the solvent after the reaction completed afforded lithium 5-(3-amino-4-formylphenyl)pentanoate (X3547-30). MS (ESI+): 222.10 (MH+). H NMR (400 MHz, MeOD): δ 9.72 (s, 1H), 7.37 (d, J=8.0 Hz, 1H), 6.57 (s, 1H), 6.55 (d, J=8.0 Hz, 1H), 2.56 (m, 2H), 2.19 (m, 2H), 1.64 (m, 4H).

Workup

  1. customRemoval of the solvent after the reaction

Sources & evidence

ORD record
ord-ced1ad4a18bc4e0780431dd426073994
Source dataset
uspto-grants-2014_07
Patent number
US08785151B2

Reaction notes

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