反应详情

A solution of the above 2-(4-ethylphenylmethyl)malononitrile (1.30 g) and hydrazine hydrate (0.86 ml) in ethanol (35 ml) was heated under reflux for 4 hours. Hydrazine hydrate (0.43 ml) was further added thereto and the mixture was further heated under reflux for 4 hours. The reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-diethyl ether to give 3,5-diamino-4-(4-ethylphenylmethyl)pyrazole (2.63 g) as pale pink powder. APCI-Mass m/Z 217 (M+H).

1. temperatureunder reflux for 4 hours
2. temperaturethe mixture was further heated
3. temperatureunder reflux for 4 hours
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was crystallized from ethyl acetate-diethyl ether