Benzene, 1-bromo-4-(trifluoromethyl)- → 2-[4-(Trifluoromethyl)phenyl]thiophene

HRID 1625863Notes

Reaction equation

HRID 1625863 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1B(O)O>>[F:9][C:8]([F:11])([F:10])[C:5]1[CH:6]=[CH:7][C:2]([C:13]2[S:12][CH:16]=[CH:15][CH:14]=2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-HCID 27339602-Thiopheneboronic acid

Product 1

HCID 121680562-[4-(Trifluoromethyl)phenyl]thiophene

Procedure

4-Bromobenzotrifluoride and thiophene-2-boronic acid were treated in a manner similar to Reference Example 20-(1) to give 2-(4-trifluoromethylphenyl)thiophene as colorless crystals.

Sources & evidence

ORD record
ord-b01eff160c10402982aa9c7a62ef7f79
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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