2-Bromo-6-fluoropyridine → 2-Fluoro-6-(thiophen-2-yl)pyridine

HRID 1625884Notes

Reaction equation

HRID 1625884 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[N:3]=1.[S:9]1[CH:13]=[CH:12][CH:11]=[C:10]1B(O)O>>[F:8][C:4]1[N:3]=[C:2]([C:10]2[S:9][CH:13]=[CH:12][CH:11]=2)[CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 6394382-Bromo-6-fluoropyridineHCID 27339602-Thiopheneboronic acid

Product 1

HCID 666080952-Fluoro-6-(thiophen-2-yl)pyridine

Procedure

2-Bromo-6-fluoropyridine and thiophene-2-boronic acid were treated in a manner similar to Reference Example 20-(1) to give 2-(6-fluoro-2-pyridyl)thiophene as yellow oil. APCI-Mass m/Z 180 (M+H).

Sources & evidence

ORD record
ord-4fa102a1bdd744ab814a9fd04982286f
Source dataset
uspto-grants-2014_07
Patent number
US08785403B2

Reaction notes

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