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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1625884Generated: November 3, 2026

2-Bromo-6-fluoropyridine → 2-Fluoro-6-(thiophen-2-yl)pyridine

https://huagongshe.com/reaction/1625884

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-6-fluoropyridineHCID 639438—
Reactant2-Thiopheneboronic acidHCID 2733960—
Product2-Fluoro-6-(thiophen-2-yl)pyridineHCID 66608095—

Reaction Steps

2-Bromo-6-fluoropyridine and thiophene-2-boronic acid were treated in a manner similar to Reference Example 20-(1) to give 2-(6-fluoro-2-pyridyl)thiophene as yellow oil. APCI-Mass m/Z 180 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08785403B2
Source datasetuspto-grants-2014_07
ORD IDord-4fa102a1bdd744ab814a9fd04982286f
Source noteuspto-grants-2014_07